Polynerv Syrup


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Thiamine HCl (Vit. B1)
Pyridoxine HCl (Vit. B6)
Cyanocobalamin (Vit. B12)


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    What is Polynerv™ Syrup?
    Polynerv syrup is a high-dose B-complex formulation containing vitamins B1, B6 and B12 which are essential for
    body growth. It is available in a strawberry flavored translucent red color syrup.

    What is Polynerv™ Syrup used for?
    Polynerv™ Syrup provides support in conditions where the requirements for B-complex vitamins are increased
    (as in growth, physiologic stress,decreased resistance to infections, chronic illnesses, metabolic disorders and in
    certain diseases of the digestive tract and nervous system). It can also be given before and after surgical

    Polynerv™ syrup is used for the prevention and treatment of vitamin B deficiency disorder arising from poor diet,
    impaired B vitamins absorption or utilization.

    These major B vitamins are frequently lacking in unbalanced diets. Even children who take substantial amounts of
    the B-complex vitamin in the diet may still suffer from deficiency disorders due to use of antibiotics and certain
    drugs which interfere with the absorption or utilization of B vitamins (i.e., isoniazid, phenothiazines, theophylline).
    Absorption of the B-complex vitamins may also be impaired due to prolonged diarrhea or excessive vomiting.

    Normal cellular activities depend on the availability of biochemical energy derived mainly from the food nutrients.
    VITAMINS B1 + B6 + B12 function as coenzymes which stimulate the various metabolic processes that produce
    the energy to fuel the cellular activities of the body. The metabolic events in which vitamins B1 + B6 + B12 play
    dominant roles as coenzymes make possible the conversion of food nutrients (carbohydrates, fats and proteins)
    into utilizable substances to form the different body compounds and tissues.

    As coenzymes, VITAMINS B1 + B6 + B12 stimulate the various cellular reactions which transform nutrients from
    food into energy which is used to convert food nutrients into utilizable substances for body growth and repair.

    THIAMINE (Vitamin B1), as a coenzyme of carbohydrate metabolism, ensures the efficient production of energy
    from glucose, the body’s chief source of energy and the conversion of glucose into other metabolites such as
    ribose, a major component of DNA.

    Glucose supplies the basic nutritional needs of the nervous system. The cells of the central nervous system
    depend entirely or almost exclusively on glucose as its major energy source. Independent of its coenzyme function, vitamin B1 acts as a
    modulator in neuromuscular transmission of impulses.

    PYRIDOXAL PHOSPHATE (Vitamin B6) plays a key role in the metabolism of amino acids, which is needed for
    cellular growth and repair. Vitamin B6 is therefore necessary in the formation of the body tissues and regulatory
    compounds. Vitamin B6 helps in the biosynthesis of porphyrin needed for the formation of blood elements. It is
    also involved in the biosynthesis of neurotransmitters such as serotonin, GABA and norepinephrine which are
    important regulatory substances in the nervous system.

    COBALAMIN (Vitamin B12) functions as a coenzyme in the synthesis of nucleic acids. Vitamin B12 is necessary
    for the formation and maturation of the red blood cells. It acts as a coenzyme in the conversion of methylmalonylCoA, required in the formation of myelin sheath of the nervous tissues. High doses of vitamins B6 and B12
    supplementation also provide support in the therapeutic management of many forms of anemia especially
    megaloblastic anemia.

    As the well-known functions of VITAMINS B1 + B6 + B12 are directed towards the CNS, the purported actions
    of high doses involve the central nervous system. Optimum nutrition of the nervous tissue is a must in the
    management of diseases causing malfunctioning of the nervous system. If the neuronal cells are deprived of its
    basic nutritional needs, the impaired neurophysiologic functions will consequently disturb the activities of other
    organs. The high doses of vitamins B1, B6 and B12 therefore help maintain the normal functioning of the
    nervous system.

    The B-complex vitamins, by virtue of their biological function as metabolic activators, provide a natural
    therapeutic support in the management of disorders arising from increased tissue demands. They are also
    indicated in situations where there is increased body requirement for energy as in growth, strenuous physical
    activities, stress during illnesses such as hypermetabolic states and infectious diseases.
    High doses of Vitamins B1 B6 B12 also provide nutritional supplement to promote appetite and weight gain.


    How should Polynerv™ Syrup be taken?
    1 – 2 years old – 1 mL (1/2 teaspoon) daily
    3 – 6 years old – 5 mL (1 teaspoonful) daily
    7 – 12 years old – 10 mL (2 teaspoonfuls) daily

    Or as prescribed by the physician


    When should you not take Polynerv™ Syrup?
    Polynerv syrup is contraindicated in patients with history of hypersensitivity to any of its components.

    What care or precautions should be observed when taking Polynerv™ Syrup?
    Polynerv syrup is contraindicated in patients with history of hypersensitivity to any of its components.

    Cyanocobalamin (Vitamin B12) should not be used to treat megaloblastic anemia of pregnancy. Administration of
    doses greater than 10 mcg of Vitamin B12 daily may produce a hematological response in patients with folate deficiency; indiscriminate use may mask the precise diagnosis.

    Cyanocobalamin or hydroxycobalamin should not be given to patients with suspected vitamin B12 deficiency without first confirming the diagnosis. Regular monitoring of the blood is recommended.

    What are the undesirable side effects of Polynerv™ Syrup?

    The B vitamins are generally safe and well tolerated.

    Adverse effects occur rarely after oral administration of thiamine and cyanocobalamin. Hypersensitivity reactions have been reported after parenteral administration of thiamine. Hypersensitivity reactions to parenteral thiamine ranged from mild to very rarely, anaphylactic shock.

    What other medicines or food should be avoided while taking Polynerv™ Syrup?
    Polynerv Syrup may reduce the effects of levodopa and altretamine. Serum concentrations of phenobarbital and phenytoin may also be decreased. Vitamin B12 absorption may be reduced by histamine-2 receptor antagonists, omeprazole and colchicine. Some drugs may increase the requirements for B complex including hydralazine, isoniazid and penicillamine.

    What should you do if you miss a dose?
    If you miss a dose, you must take it as soon as possible. Do not double the next dose to make up for the missed
    one. You may skip the missed dose and continue your regular dosing schedule if it is almost time for the next

    What are the signs and symptoms of overdose and what to do when you have taken more than recommended dosage?No cases of Vitamin B1 overdose have been reported. Vitamin B6 and Vitamin B12 overdose are rare. Although
    an overdose is highly unlikely, call the doctor right away if you have any reason to suspect that one has occurred.

    How should Polynerv™ Syrup be stored?
    Polynerv syrup should be stored in a tightly sealed container away from heat, moisture and light.
    Store at temperatures not exceeding 30 C. Keep the medicine out of reach of children.

    When should you consult your doctor?
    Generally, any untoward adverse effects experienced with Polynerv Syrup should immediately be reported to
    your doctor.

    What is in Polynerv™ Syrup?

    Thiamine Hydrochloride (Vitamin B1) – 100 mg
    Pyridoxine Hydrochloride (Vitamin B6) – 5 mg
    Cyanocobalamin (Vitamin B12) 50 mcg