The combination of Tramadol HCI and Paracetamol provides double analgesic benefits for moderate to severe pain. Tramadol is an opioid analgesic which acts on the central nervous system to block the transmission of pain signals. Tramadol mimics the action of the naturally occurring pain relieving chemical, endorphins, found in the brain and spinal cord. Endorphin reduces pain by binding to opioid receptors. This blocks the transmission of pain signals sent by the nerves to the brain. Tramadol also has noradrenergic and serotonergic properties that may contribute to its analgesic activity. Tramadol also works by enhancing the activity of neurotransmitters serotonin and noradrenaline in the brain and spinal cord. These are chemical compounds that act as chemical messengers between nerve cells which also help relieve pain.
Paracetamol is a para-aminophenol derivative which has analgesic and antipyretic properties, and a weak anti-inflammatory activity. Paracetamol relieves pain by blocking the production of prostaglandin, the chemical that causes pain, through the inhibition of the enzyme cyclooxygenase. The combination of tramadol and paracetamol provides synergistic effect to relieve moderate to severe pain.