Macrobee with Iron (Reformulated) Tablet


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What is in Macrobee with Iron Film-Coated Tablet?

No. of Servings per container/pack: 60 Tablets

Each film-coated tablet contains:

  • Folic Acid (Vitamin B9) 1 mg
  • Cyanocobalamin (Vitamin B12) 50 mcg
  • Ascorbic Acid (Vitamin C) 100 mg
  • Ferrous Fumarate 250 mg (equivalent to Elemental Iron 82.50 mg)
  • Manganese Sulfate Monohydrate 200 mcg
  • Cupric Sulfate Pentahydrate 200 mg

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    What is Macrobee with Iron Film-Coated Tablet?

    Macrobee with Iron is a pink, oblong, film-coated tablet and plain on both sid

    Macrobee with Iron Film-Coated tablet is a therapeutic iron preparation reinf with minerals and vitamin C for the effective management of anemias among adolescents, pregnant women and the elderly. Its reliable and broad hematin anemic efficacy is derived from the functional capacities of its components. primary ingredient is ferrous fumarate, a clinically proven hematopoietic facto Vitamin C and cupric sulfate are also added for enhanced iron absorption an utilization. Vitamin B12 and Folic Acid further ensure wider anti-anemia cove These active substances, which individually exhibit well-defined therapeutic and which mutually complement each other, place Multivitamins +Iron (Macr with Iron) Film-Coated Tablet in the class of select formulations which offer comprehensive coverage in the management of anemias.

    What is Macrobee with Iron Film-Coated Tablet used for?

    Macrobee with Iron film coated tablet is indicated for the prevention of iron deficiency anemia specially in periods of rapid adolescent growth, pregnanc lactation, excessive menstrual flow and old age.

    Macrobee with Iron Film-Coated tablet is used for the treatment of Iron Defic

    Anemia associated with traumatic or endogenous hemorrhages, surgery on gastrointestinal tract and malnutrition.

    How should Macrobee with Iron Film-Coated Tablet be taken?

    One tablet per day or as prescribed by the physician.

    It is best taken on an empty stomach, although it can be taken with a small a of food to avoid gastrointestinal problems.

    When should you not take Macrobee with Iron Film-Coated Tablet?

    Macrobee with Iron Film-Coated Tablet should not be taken by patients with of hypersensitivity or allergic reaction to any of its components.

    It should not be taken by patients receiving repeated blood transfusion or by patients with anemias not caused by iron deficiency unless iron deficiency is present.

    What care or precautions should be observed when taking Macrobee with I Film-Coated Tablet?

    Do not exceed the recommended daily dose.

    Macrobee with Iron Film-Coated tablet should be used with caution in patie gastrointestinal disorders, since iron salts can exacerbate gastrointestinal bl

    Particular care should be taken by patients with iron storage or iron absorpti diseases such as hemochromatosis and hemoglobinopathies. Macrobee wit Film-Coated tablet should be given with caution to patients with existing gastrointestinal diseases such as inflammatory bowel disease, intestinal stric and diverticulae.

    What are the undesirable side effects of Macrobee with Iron Film-Coated Ta

    As with all iron preparations, the stool may become black after taking this formulation. However, this is completely harmless.

    Oral iron supplements have been associated with hypersensitivity reactions include anaphylaxis and skin reactions such as rash, pruritus, urticaria, edem photosensitivity.

    Gastrointestinal irritation and abdominal pain with nausea and vomiting, diarr constipation may be experienced. These effects, which are usually related to amount of elemental iron taken, may be reduced by taking the medicine with after food or by beginning therapy with a small dose and increasing graduall

    Ascorbic acid is usually well tolerated. Large doses may cause hyperoxaluria kidney stones, hemolysis in patients with G6PD deficiency, diarrhea, and oth gastrointestinal disturbances.

    Copper salts may produce severe gastrointestinal effects and there may be systemic absorption of copper.

    Cyanocobalamin may cause gastrointestinal disturbances, fever, chills, hot fl dizziness, malaise, acneiform, bullous eruptions, and tremors.

    What other medicines or food should be avoided while taking Macrobee wit Film-Coated Tablet?

    Iron salts are poorly absorbed orally and food may affect absorption. Compo containing calcium and magnesium, including antacids and mineral supplem bicarbonates, carbonates, oxalates or phosphates may affect absorption of i the formation of insoluble complexes. Zinc salts also decrease the absorptio iron.

    The absorption of both iron salts and tetracyclines is diminished when taken together orally. If treatment with both drugs is required, a time interval of abo 3 hours should be allowed between them.

    Time interval is also advised for patients taking trientine and iron supplement

    The response to iron may be delayed in patients receiving systemic chloramphenicol.

    Iron is chelated by acetohydroxamic acid, reducing the absorption of both. Ir should not be given with dimercaprol as toxic complexes may form.

    Iron salts can also decrease the absorption, bioavailability and clinical effect following drugs: cefdinir, bisphosphonates (e.g., alendronate), doxycycline, entacapone, fluoroquinolones, levodopa, methyldopa, mycophenolate mofeti penicillamine. Iron salts may reduce the efficacy of levothyroxine.

    Omeprazole may affect the bioavailability of dietary vitamin C and reduce the absorption of Cyanocobalamin (Vitamin B12).

    Absorption of vitamin B12 from the gastrointestinal tract may be reduced by neomycin, aminosalicylic acid, histamine–2 receptor antagonists and colchic

    What should you do if you miss a dose?

    If you miss a dose, you must take it as soon as possible. Do not double the dose to make up for the missed one. You may skip the missed dose and con your regular dosing schedule if it is almost time for the next dose.

    What are the signs and symptoms of overdose and what to do when you ha taken more than the recommended dosage?

    Iron overload may occur as a result of excessive or mistaken therapy especi injectable therapy which may lead eventually to hemochromatosis, where pig

    deposition in skin and other organs may occur, mild liver dysfunction, endoc dysfunction (e.g. failure of the adolescent growth spurt, hypogonadism, som diabetes and hypothyroidism), and heart disease (pericarditis, heart failure a arrhythmia). Serum iron concentrations have also been used as an indication severity of overdosage. If unchecked, the iron build-up can lead to death.

    In cases of iron overdose, the stomach should be emptied by gastric lavage administering deferoxamine preferably within one hour of ingesting a signific amount of iron.

    Administration of vitamin B12 with doses greater than 10 mcg daily may pro hematological response in patients with folate deficiency. Indiscriminate use mask the precise diagnosis.

    Acute poisoning due to ingestion of manganese or manganese salts is rare.

    How should Macrobee with Iron Film-coated tablet be stored?

    Store at temperatures not exceeding 30 degree C. Keep the medicine out of reach children.

    When should you consult your doctor?

    Generally, any untoward adverse effects experienced with Macrobee with Iro Coated Tablet should immediately be reported to your doctor.

    For suspected adverse drug reaction, report to the FDA:



    Manufactured for:
    5/F S.V. More Group Corporate Center
    #16 Scout Tuazon cor. Roces Ave., Quezon City
    Metro Manila, Philippines
    by: Hizon Laboratories, Inc.
    Assumption Rd., Sumulong Highway, Antipolo City

    Date of Renewal of the Authorization: 03 June 2020
    Date of Revision of Patient Information Leaflet: 28 May 2020