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New Research Affirms Benefits of Daily Multivitamin Supplements for Cognitive Health

As we age, maintaining our cognitive health becomes increasingly important. A new research confirms statistically significant benefits of a daily multivitamin versus placebo for both memory and global cognition.

A groundbreaking study from Mass General Brigham, published in January 2024, highlights the benefits of daily multivitamin and mineral supplements. This extensive study, part of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS), included over 5,000 participants and found that those who took multivitamins experienced significant improvements in memory and overall cognitive function compared to those who took a placebo. This suggests that multivitamins could help prevent memory loss and cognitive decline as we get older.

Expanding on this, a comprehensive review by Fekete and colleagues in 2023 examined various nutritional supplements and their effects on brain health. This review looked at vitamins, minerals, antioxidants, and other dietary supplements, highlighting their potential to enhance cognitive function and reduce the risk of cognitive decline.

Key Nutrients for Cognitive Health

B Vitamins: Vitamins B6, B9 (folate), and B12 are crucial for maintaining brain function. They help reduce levels of homocysteine, an amino acid linked to brain diseases when present in high amounts. Studies show that these vitamins can slow cognitive decline and improve brain function, especially in older adults.

Antioxidants: Vitamins C and E, selenium, and polyphenols like resveratrol and curcumin protect the brain from oxidative stress, which can damage brain cells and lead to cognitive decline. These antioxidants help maintain memory, concentration, and overall brain health.

Vitamin D: Known as the “sunshine vitamin,” vitamin D is essential for brain health. It supports blood flow to the brain and helps produce neurotransmitters like dopamine and serotonin, which regulate mood and cognitive functions.


The growing evidence supporting the benefits of nutritional supplements for brain health is promising. Daily multivitamins, along with targeted supplements of specific vitamins, minerals, and antioxidants, offer a simple way to help maintain cognitive function and prevent cognitive decline as we age.

By incorporating these supplements into our daily routine, along with a healthy diet and lifestyle, we can better protect our brain health and enjoy a more vibrant, active life as we grow older. As research continues, the role of nutritional supplements in cognitive health will likely become even more significant, offering new ways to enhance mental well-being and overall quality of life.

For guidance on the benefits and proper use of multivitamins and minerals based on your specific health conditions or illnesses, it is always best to consult your physician.


1. Third major study finds evidence that daily multivitamin supplements improve memory and slow cognitive aging in older adults. [Mass General Brigham]( Published Jan. 18, 2024.

2. Fekete M, Lehoczki A, Tarantini S, et al. Improving Cognitive Function with Nutritional Supplements in Aging: A Comprehensive Narrative Review of Clinical Studies Investigating the Effects of Vitamins, Minerals, Antioxidants, and Other Dietary Supplements. Nutrients. 2023;15(24):5116. Published 2023 Dec 15. doi:10.3390/nu15245116